Champignon Hydne hérisson, Hericium erinaceum

Hericium erinaceus (Bull.) Pers.

 L’hydne hérisson, au japon Yamabushitake (champignons des moines de la montagne) ou Houtou est utilisé de longue date en médecine traditionnelle et par exemple en Chine contre les douleurs d’estomac et certains cancers. Des polysaccharides aux vertus anti tumorales sont étudiés depuis plus de 30 ans. Il est utilisé pour la régénération des nerfs (producteur de myéline) et contre la sénilité.

Voici un petit aperçu des 63 études  publiés depuis 1992

• Ostéoporose (5)
  
• Cancer  (2, 8, 9, )
  
• Apoptose (8)
  
• Antioxydant (6)
  
• Antifongique (5, 6)
  
• Anti-inflammatoire (11)
• Antisenescence (3,7)
  
• Polysaccharides anti-tumeurs (9)
• Fibrinolytique (10)
• propriétés neurologiques (12)
• Equilibre du microbiote
• Dépression (14)

1.Durmus A, Durmus I, Bender O, Karatepe O. The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats. Korean J Intern Med. 2021 Mar;36(Suppl 1):S44-S52. doi: 10.3904/kjim.2019.050. Epub 2020 Jun 19. PMID: 32550720; PMCID: PMC8009150.

2.Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9. PMID: 32274562.

3.Kim SK, Son CG, Yun CH, Han SH. Hericium erinaceum induces maturation of dendritic cells derived from human peripheral blood monocytes. Phytother Res. 2010 Jan;24(1):14-9. doi: 10.1002/ptr.2849. PMID: 19441068.

4.Xu H, Wu PR, Shen ZY, Chen XD. Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities. Int J Biol Macromol. 2010 Jul 1;47(1):33-6. doi: 10.1016/j.ijbiomac.2010.03.024. Epub 2010 Apr 7. PMID: 20380848.

5.Li W, Lee SH, Jang HD, Ma JY, Kim YH. Antioxidant and Anti-Osteoporotic Activities of Aromatic Compounds and Sterols from Hericium erinaceum. Molecules. 2017 Jan 11;22(1):108. doi: 10.3390/molecules22010108. PMID: 28085076; PMCID: PMC6155785.

6.Lu QQ, Tian JM, Wei J, Gao JM. Bioactive metabolites from the mycelia of the basidiomycete Hericium erinaceum. Nat Prod Res. 2014;28(16):1288-92. doi: 10.1080/14786419.2014.898145. Epub 2014 Mar 18. PMID: 24635196.

7.Noh HJ, Yang HH, Kim GS, Lee SE, Lee DY, Choi JH, Kim SY, Lee ES, Ji SH, Kang KS, Park HJ, Kim JR, Kim KH. Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells. J Enzyme Inhib Med Chem. 2015 Dec;30(6):934-40. doi: 10.3109/14756366.2014.995181. Epub 2015 Feb 13. PMID: 25676326.

8.Li W, Zhou W, Kim EJ, Shim SH, Kang HK, Kim YH. Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities. Food Chem. 2015 Mar 1;170:336-42. doi: 10.1016/j.foodchem.2014.08.078. Epub 2014 Aug 23. PMID: 25306354

9.Mizuno T, Wasa T, Ito H, Suzuki C, Ukai N. Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Biosci Biotechnol Biochem. 1992 Feb;56(2):347-8. doi: 10.1271/bbb.56.347. PMID: 1368310.

10. Choi BS, Sapkota K, Choi JH, Shin CH, Kim S, Kim SJ. Herinase: a novel bi-functional fibrinolytic protease from the monkey head mushroom, Hericium erinaceum. Appl Biochem Biotechnol. 2013 Jun;170(3):609-22. doi: 10.1007/s12010-013-0206-2. Epub 2013 Apr 7. PMID: 23564433.

11. Noh HJ, Yoon JY, Kim GS, Lee SE, Lee DY, Choi JH, Kim SY, Kang KS, Cho JY, Kim KH. Benzyl alcohol derivatives from the mushroom Hericium erinaceum attenuate LPS-stimulated inflammatory response through the regulation of NF-κB and AP-1 activity. Immunopharmacol Immunotoxicol. 2014 Oct;36(5):349-54. doi: 10.3109/08923973.2014.947036. Epub 2014 Aug 4. PMID: 25090632.

12. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018 May 21;2018:5802634. doi: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.

13. Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PMID: 26244378.

14. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceusfor Depressive Disorder. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. PMID: 31881712; PMCID: PMC6982118.