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Coleus Forskohlii

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    Around 470 studies confirm the experience of Ayurveda (traditional Indian medicine) in the uses of this plant which is now prized in Asia and particularly in Japan for its slimming properties.

    Ethnobotany :

    Used since Antiquity for the treatment of heart disease, abdominal colic, respiratory disorders.

    Components :

    chamaecydin,  6 alpha-hydroxydemethylcryptojaponol, alpha-cedrene, oleanolic acid, forskolin G, forskolin J, ,6 -diacetyl-9-deoxyforskolin, forskolin A, forskolin H, 6-acetyl-1-deoxyforskolin, betulinic acid, beta-sitosterol,

    Study results :

    -Reduction of cataracts (by reducing blood pressure, reducing glucose levels and restoring the level of anti-oxidant enzymes) (1)

    -Obesity (2,4,5)

    -Athma (3)

    -Hypertension (4)

    -HIV (6)

    -Cancer, apoptosis (7)

    1. Soni P, Bodakhe SH. Protective effect of Coleus forskohlii leaf-extract compound on progression of cataract against Fructose-Induced experimental cataract in rats. Drug Chem Toxicol. 2022 Jan;45(1):170-179. doi:10.1080/01480545.2019.1668404. Epub 2019 Sep 24. PMID: 31547727.

    2. Loftus HL, Astell KJ, Mathai ML, Su XQ. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015 Nov 17;7(11):9508-22. doi:10.3390/nu7115483. PMID: 26593941; PMCID: PMC4663611.

    3.Ma C, Zou L, Xia Y, Tu Y, Xue D, Yang Y, Liu D, Liu Y, Wu H, Dan H, You P. Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix . J Cell Biochem. 2019 Jun;120(6):9648-9655. doi:10.1002/jcb.28243. Epub 2018 Dec 5. PMID: 30520122.

    4. Jagtap M, Chandola HM, Ravishankar B. Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric population. Ayu. 2011 Jan;32(1):59-65. doi:10.4103/0974-8520.85729. PMID: 22131759; PMCID: PMC3215419.

    5. Henderson S, Magu B, Rasmussen C, Lancaster S, Kerksick C, Smith P, Melton C, Cowan P, Greenwood M, Earnest C, Almada A, Milnor P, Magrans T, Bowden R, Ounpraseuth S, Thomas A, Kreider RB. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. J Int Soc Sports Nutr. 2005 Dec 9;2(2):54-62. doi:10.1186/1550-2783-2-2-54. PMID: 18500958; PMCID: PMC2129145.

    6. Bodiwala HS, Sabde S, Mitra D, Bhutani KK, Singh IP. Anti-HIV diterpenes from Coleus forskohlii. Nat Prod Commun. 2009 Sep;4(9):1173-5. PMID: 19831022.

    7.Sapio L, Gallo M, Illiano M, Chiosi E, Naviglio D, Spina A, Naviglio S. The Natural cAMP Elevating Compound Forskolin in Cancer Therapy : Is It Time? J Cell Physiol. 2017 May;232(5):922-927. doi:10.1002/jcp.25650. Epub 2016 Nov 20. PMID: 27739063.

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