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Asparagus racemosus, Shatavari (root)

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    Asparagus racemosus Willd.

    Ethnopharmacology

    Used since antiquity in Greek, Chinese and Ayurvedic medicine, 

    Unani Medicine  (in Arabic “coming from the Greeks)

    (as well as Sumer, Mesopotamia, Egypt), 

    Siddha Medicine, Tamil (India,  Tamilnadu) 

     Use in Ayurvedic medicine (rasayana plant):

    -Nervous tonic for women

    -gastric ulcers (prevention and treatment)

    -dyspepsia

    -galactogogue

    -nervous disorders, stress management

    -inflammation

    -liver diseases

    -Infectious diseases

    -fertility

    -diarrhea, dysentery

    -antioxidant

    -antitussive

    Composition

    fructo-oligosaccharides, polysaccharides, asparosides, shatavarins, sapogenins, racemosols, isoflavones, glycosides, mucilages, fatty acids, saponin


    Studies 

    According to studies, the activity of Asparagus racemosus on the endocrine sphere is particularly important, confirming among other things the Ayurvedic use on epilepsy.

    -neurological disorders, neuro protective (1,)

    -antioxidant (1,)

    -anti-inflammatory  (1,)

    -nootropic (1,)

    -stress, anxiety, depression, epilepsy, Parkinson's disease, Alzheimer's disease (1,)

    -phytoestrogenic (2, 

    -withdrawal syndrome (2,)

    -increases antioxidant enzymes: SOD, GSH peroxidase, GSH and catalase in certain regions of the brain  : Hippocampus, prefrontal cortex, amygdala, hypothalamus (2)

    - increases hormonal activity and mainly norepinephrine and serotonin (5-HT) in the amygdala. It can also increase the expression of 5-HT2A receptors in the amygdala (neuropathic anti-inflammatory). A GABA-mediated mechanism has also been demonstrated. (3)

    -Modulation of stress pathways, renewal of monoamines and their metabolites. (4)

    -Antidepressant activity mediated by the monoaminergic system, nootropic and anti-amnesic activities by the cholinergic system. (5)

    -Depression and epilepsy. (6.)


    1 . Majumdar S, Gupta S, Prajapati SK, Krishnamurthy S. Neuro-nutraceutical potential of Asparagus racemosus: A review. Neurochem Int. 2021 May;145:105013. doi: 10.1016/j.neuint.2021.105013. Epub 2021 Mar 6. PMID: 33689806.

    2 . Bopana N, Saxena S. Asparagus racemosus--ethnopharmacological evaluation and conservation needs. J Ethnopharmacol. 2007 Mar 1;110(1):1-15. doi: 10.1016/j.jep.2007.01.001. Epub 2007 Jan 4. PMID: 17240097.

    3. Garabadu D, Krishnamurthy S. Asparagus racemosus attenuates anxiety-like behavior in experimental animal models. Cell Mol Neurobiol. 2014 May;34(4):511-21. doi:10.1007/s10571-014-0035-z. Epub 2014 Feb 21. PMID: 24557501.

    4. Krishnamurthy S, Garabadu D, Reddy NR. Asparagus racemosus modulates the hypothalamic-pituitary-adrenal axis and brain monoaminergic systems in rats. Nutr Neurosci. 2013 Nov;16(6):255-61. doi:10.1179/1476830513Y.0000000053. Epub 2013 Mar 6. PMID: 23485433.

    5. Meena J, Ojha R, Muruganandam AV, Krishnamurthy S. Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes. Neurosci Lett. 2011 Sep 26;503(1):6-9. doi: 10.1016/j.neulet.2011.07.051. Epub 2011 Aug 6. PMID: 21843599.

    6. Pahwa P, Singh T, Goel RK. Anticonvulsant Effect of Asparagus racemosus Willd. in a Mouse Model of Catamenial Epilepsy. Neurochem Res. 2022 Feb;47(2):422-433. doi:10.1007/s11064-021-03455-2. Epub 2021 Oct 8. PMID: 34623565.

    Category: Ayurvedic and tropical plants

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