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Cedrus Atlantica glauca, Blue Atlas cedar (cone)

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    Cedrus Atlantica glauca (Endl.) is mainly present in Morocco and Algeria and is used in ethnobotany on the genitourinary, musculoskeletal and cutaneous systems.

    Component of the cones (5):

    9alpha,13alpha-epidioxiabiet-8(14)-en-18-ol, 7alpha,18-diacetoxy, 9beta,13beta-epidioxiabiet-8(14)-ene, 7alpha,18-diacetoxyabiet-8(14)-ene-13beta -ol, 7alpha,18-diacetoxy-13beta-methoxyabiet-8(14)-ene and 13beta-hydroxyabiet-8(14)-en-7-un

    -cedrol (sesquiterpene alcohol = ) antimicrobial, anti-inflammatory, analgesic, anxiolytic and anticancer effects

    Studies :

    -Apoptosis (colorectal cancer) (1.8)

    -Inhibition of leukemia cell growth (2)

    -Destruction of part of the glioblastoma cells (malignant brain tumor) (2)

    -Apoptosis of leukemia cells (acute myeloid leukemia) (3)

    -Reduction of K562 cells (Leukemia)  (7)

    -Potential anti-cancer (hepatocellular carcinoma) (4)

    -Apoptosis (4.8)

    -Anti-bacterial activity of the cones (6)

    1. Huang CY, Chien JH, Chang KF, Hsiao CY, Huang YC, Chen YT, Hsu MY, Hsieh MC, Tsai NM. Cedrus atlantica extract exerts antiproliferative effect on colorectal cancer through the induction of cell cycle arrest and apoptosis. Food Sci Nutr. 2022 Feb 21;10(5):1638-1648. doi:10.1002/fsn3.2786. PMID: 35592288; PMCID: PMC9094448.

    2. Chang KF, Chang JT, Huang XF, Huang YC, Li CY, Weng JC, Hsiao CY, Hsu HJ, Tsai NM. Cedrus atlantica Extract Suppress Glioblastoma Growth through Promotion of Genotoxicity and Apoptosis: In Vitro and In Vivo Studies. Int J Med Sci. 2021 Apr 22;18(11):2417-2430. doi:10.7150/ijms.54468. PMID: 33967620; PMCID: PMC8100640.

    3. Hung PH, Hsieh MC, Lee SC, Huang XF, Chang KF, Chen SY, Lee MS, Tsai NM. Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis. Mol Biol Rep. 2020 Nov;47(11):8935-8947. doi:10.1007/s11033-020-05947-w. Epub 2020 Nov 4. PMID: 33150524.

    4. Huang XF, Chang KF, Lee SC, Sheu GT, Li CY, Weng JC, Hsiao CY, Tsai NM. Extract Derived from Cedrus atlantica Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo. Molecules. 2020 Oct 10;25(20):4608. doi:10.3390/molecules25204608. PMID: 33050385; PMCID: PMC7594045.

    5. Barrero AF, Quílez del Moral JF, Mar Herrador M, Arteaga JF, Akssira M, Benharref A, Dakir M. Abietane diterpenes from the cones of Cedrus atlantica. Phytochemistry. 2005 Jan;66(1):105-11. doi: 10.1016/j.phytochem.2004.10.017. PMID: 15649517.

    6. Dakir M, El Hanbali F, Mellouki F, Akssira M, Benharref A, Quilez Del Moral JF, Barrero AF. Antibacterial diterpenoids from Cedrus atlantica . Nat Prod Res. 2005 Oct;19(7):719-22. doi:10.1080/14786410512331330675. PMID: 16076643.

    7. Saab AM, Lampronti I, Borgatti M, Finotti A, Harb F, Safi S, Gambari R. In vitro evaluation of the anti-proliferative activities of the wood essential oils of three Cedrus species against K562 human chronic myelogenous leukaemia cells . Nat Prod Res. 2012;26(23):2227-31. doi:10.1080/14786419.2011.643885. Epub 2011 Dec 14. PMID: 22168262.

    8. Chien JH, Chang KF, Lee SC, Lee CJ, Chen YT, Lai HC, Lu YC, Tsai NM. Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death. Int J Med Sci. 2022 Oct 31;19(13):1953-1964. doi:10.7150/ijms.77719. PMID: 36438926; PMCID: PMC9682504.

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