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Ananas comosus, Pineapple (fruit)

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    Pineapple comosus

    480 studies confirm the interest of science for the main enzyme of Pineapple: Bromelain, anti-edematous, anti-inflammatory, anti-cancer, anti-thrombotic, fibrinolytic, this enzyme is capable of competing  (to interfere) with the growth of malignant cells and therefore to promote their apoptosis  (self-destruction of cells without inflammation following a signal) (study No. 1,2,4). Research shows beneficial effects on the respiratory, digestive and circulatory systems,  on the immune system, on the symptoms of arthritis and joint pain (4).

    Studies :

    -Anti-inflammatory (1,2,3,5,6,7,8)

    -Anti-oxidant (7)

    -Fibrinolytic (1,2,7)

    -Cardio protective (8)

    -Apoptosis (1,2,4)

    -Inhibition of platelet aggregation (2)

    -Reduction of healing time (5)

    1. Varilla C, Marcone M, Paiva L, Baptista J. Bromelain, a Group of Pineapple Proteolytic Complex Enzymes ( Ananas comosus ) and Their Possible Therapeutic and Clinical Effects. A Summary. Foods. 2021 Sep 23;10(10):2249. doi:10.3390/foods10102249. PMID: 34681298; PMCID: PMC8534447.

    2.Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1988 Feb-Mar;22(2):191-203. doi: 10.1016/0378-8741(88)90127-4. PMID: 3287010.

    3.Ajayi AM, Coker AI, Oyebanjo OT, Adebanjo IM, Ademowo OG. Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models. J Ethnopharmacol. 2022 Jan 10;282:114576. doi: 10.1016/j.jep.2021.114576. Epub 2021 Aug 27. PMID: 34461191.

    4. Chakraborty AJ, Mitra S, Tallei TE, Tareq AM, Nainu F, Cicia D, Dhama K, Emran TB, Simal-Gandara J, Capasso R. Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective. Life (Basel). 2021 Apr 6;11(4):317. doi:10.3390/life11040317. PMID: 33917319; PMCID: PMC8067380.

    5.Golezar S. Ananas comosus Effect on Perineal Pain and Wound Healing After Episiotomy: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Iran Red Crescent Med J. 2016 Mar 1;18(3):e21019. doi: 10.5812/ircmj.21019. PMID: 27247780; PMCID: PMC4884440.

    6.Kargutkar S, Brijesh S. Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology. 2018 Apr;26(2):469-477. doi:10.1007/s10787-017-0379-3. Epub 2017 Aug 1. PMID: 28766086.

    7.Ajayi AM, John KA, Emmanuel IB, Chidebe EO, Adedapo ADA. High-fat diet-induced memory impairment and anxiety-like behavior in rats attenuated by peel extract of Ananas comosus fruit via atheroprotective, antioxidant and anti-inflammatory actions . Metabol Open. 2021 Jan 4;9:100077. doi: 10.1016/j.metop.2021.100077. PMID: 33490944; PMCID: PMC7808950.

    8. Seenak P, Kumphune S, Malakul W, Chotima R, Nernpermpisooth N. Pineapple consumption reduced cardiac oxidative stress and inflammation in high cholesterol diet-fed rats. Nutr Metab (Lond). 2021 Apr 7;18(1):36. doi:10.1186/s12986-021-00566-z. PMID: 33827626; PMCID: PMC8028712.

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