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Albizia julibrissin (flower and seed)

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    Albizia julibrissin

    This macerate of Abizia julibrissim flowers and seeds is certified organic by Ecocert (FR-BIO-01) and  guaranteed 100% grown, harvested and processed on site (Lot) by us.

    129 studies since the 1960s

    Ethnobotany :

    The first written testimony of a medicinal use of Albizia julibrissin dates back to 1624 in China in a decoction “Hehuan Yin” recounted in the book “Jingle Quanshu” and it was associated with Ampelopsis japonica.

    It is also involved in Unconscious Symbolic Compensation.

    Anti-tumor components :

    Triterpenoid saponin: julibroside J(28), julibroside J(29), julibroside J(30) (2),  julibroside J(31)

    Other components : 

    hypersaccharide (apoptosis, anti-inflammatory, diuretic) (9,10)

    quercitrin (possible intestinal repair following mucosal damage) (9)

    Studies :

    -Insomnia (1)

    -Memory improvement (1)

    -Anti-tumor (2,3)

    -Neuroprotective (4)

    -Anti emetic (4)

    -Anti-obesity, inhibition of adipogenesis (5)

    -Polycystic ovaries (6)

    -Symptoms of insulin resistance (6)

    -Anti-angiogenic properties ( fights tumor growth by preventing the formation of new blood vessels) (7,8)

    -Hyperosides preventing cell invasion and migration  A 549 (lung cancer) (10)

    1. Chang JS, Liu HP, Cheng J, Chen CJ, Hwang SL, Tseng CC, Hsu LF, Lin WY. Albizia julibrissin Improves Memory Loss Induced by Insomnia in Drosophila . Evid Based Complement Alternat Med. 2019 Apr 1;2019:7395962. doi:10.1155/2019/7395962. PMID: 31057652; PMCID: PMC6463593.

    2.Zheng L, Zheng J, Zhao Y, Wang B, Wu L, Liang H. Three anti-tumor saponins from Albizia julibrissin. Bioorg Med Chem Lett. 2006 May 15;16(10):2765-8. doi: 10.1016/j.bmcl.2006.02.009. Epub 2006 Feb 28. PMID: 16504508.

    3.Roy B, Pramanik K, Mukhopadhyay B. Synthesis of a tetra- and a trisaccharide related to an anti-tumor saponin "Julibroside J28" from Albizia julibrissin . Glycoconj J. 2008 Feb;25(2):157-66. doi:10.1007/s10719-007-9068-6. Epub 2007 Aug 16. PMID: 17701454.

    4.Ebrahimzadeh MA, Fathi H, Ziar A, Mohammadi H. Attenuation of brain mitochondria oxidative damage by Albizia julibrissin Durazz: neuroprotective and antiemetic effects . Drug Chem Toxicol. 2019 Mar;42(2):122-129. doi:10.1080/01480545.2017.1413106. Epub 2017 Dec 18. PMID: 29250976.

    5. Yahagi T, Daikonya A, Kitanaka S. Flavonol acylglycosides from flower of Albizia julibrissin and their inhibitory effects on lipid accumulation in 3T3-L1 cells. Chem Pharm Bull (Tokyo). 2012;60(1):129-36. doi: 10.1248/cpb.60.129. PMID: 22223384.

    6. Wu YY, Li SY, Zhu HQ, Zhuang ZM, Shao M, Chen FL, Liu CS, Tang QF. Network pharmacology integrated with experimental validation reveals the regulatory mechanism of action of Hehuan Yin decoction in polycystic ovary syndrome with insulin resistance. J Ethnopharmacol. 2022 May 10;289:115057. doi: 10.1016/j.jep.2022.115057. Epub 2022 Feb 1. PMID: 35121050.

    7. Hua H, Feng L, Zhang XP, Zhang LF, Jin J. Anti-angiogenic activity of julibroside J8, a natural product isolated from Albizia julibrissin. Phytomedicine. 2009 Aug;16(8):703-11. doi: 10.1016/j.phymed.2009.01.002. Epub 2009 May 6. PMID: 19423313.

    8. Cai W, Li Y, Yi Q, Xie F, Du B, Feng L, Qiu L. Total saponins from Albizia julibrissin inhibit vascular endothelial growth factor-mediated angiogenesis in vitro and in vivo. Mol Med Rep. 2015 May;11(5):3405-13. doi: 10.3892/mmr.2015.3228. Epub 2015 Jan 20. PMID: 25607254; PMCID: PMC4368075.

    9. Ekenseair AK, Duan L, Carrier DJ, Bransby DI, Clausen EC. Extraction of hyperoside and quercitrin from mimosa (Albizia julibrissin) foliage . Appl Biochem Biotechnol. 2006 Spring;129-132:382-91. doi:10.1385/abab:130:1:382. PMID: 16915655.

    10. Yang Y, Sun Y, Guo X, Zhong C, Li Z. Hyperoside inhibited the migration and invasion of lung cancer cells through the upregulation of PI3K/AKT and p38 MAPK pathways . Int J Clin Exp Pathol. 2017 Sep 1;10(9):9382-9390. PMID: 31966810; PMCID: PMC6965916.

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