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Cupressus sempervirens, Cypress

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    Cupressus semprevirens L.

    Ethnopharmacology

    The cypress, like many of its coniferous congeners, has a lot been used in traditional medicine. It is particularly here for the treatment of problems related to the urinary, digestive, nervous, respiratory and integumentary systems ( hair, nails).

    Components :

    phytochemicals: monoterpenes, diterpenes, flavonoid glycosides and bioflavonoids

    -Antiseptic, astringent, anti-inflammatory, antiperspirant, diuretic and antispasmodic (1)

    Around 200 studies :

    The very paltry number of new studies concerning it are a real shame, particularly because it has exceptional qualities at the osteo-articular level, for example for osteoporosis, thanks in particular to its very high level of available organic silica. This rare quality in plants (bioavailability) certainly explains its other virtues:

    -Hyperuricemia

    - Antiulcerogenic activity (3)

    -Inhibitory activity against the enzymes glycogen phosphorylase and glucose-6-phosphatase (4)

    -Improvement of liver and kidney functions (hepatotoxicity and nephrotoxicity) (5)

    -Osteoporosis (6)

    -Benign prostatic hypertrophy (7)

    1. Batiha GE, Teibo JO, Shaheen HM, Akinfe OA, Awad AA, Teibo TKA, Alexiou A, Papadakis M. Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens . Naunyn Schmiedebergs Arch Pharmacol. 2022 Nov 17. doi: 10.1007/s00210-022-02326-z. Epub ahead of print. PMID: 36385684.

    2. Linani A, Serseg T, Benarous K, Bou-Salah L, Yousfi M, Alama MN, Ashraf G M. Cupressus sempervirens L. flavonoids as potent inhibitors to xanthine oxidase : in vitro, molecular docking, ADMET and PASS studies. J Biomol Struct Dyn. 2022 Aug 24:1-14. doi:10.1080/07391102.2022.2114943. Epub ahead of print. PMID: 36001586.

    3. Koriem KM, Gad IB, Nasiry ZK. Protective effect of Cupressus sempervirens extract against indomethacin-induced gastric ulcer in rats. Interdiscip Toxicol. 2015 Mar;8(1):25-34. doi: 10.1515/intox-2015-0006. PMID: 27486357; PMCID: PMC4961923.

    4. Rawat P, Khan MF, Kumar M, Tamarkar AK, Srivastava AK, Arya KR, Maurya R. Constituents from fruits of Cupressus sempervirens . Fitoterapia. 2010 Apr;81(3):162-6. doi: 10.1016/j.fitote.2009.08.014. Epub 2009 Aug 15. PMID: 19686818.

    5. Ali SA, Rizk MZ, Ibrahim NA, Abdallah MS, Sharara HM, Moustafa MM. Protective role of Juniperus phoenicea and Cupressus sempervirens against CCl(4) . World J Gastrointest Pharmacol Ther. 2010 Dec 6;1(6):123-31. doi:10.4292/wjgpt.v1.i6.123. PMID: 21577307; PMCID: PMC3091159.

    6. Khan MF, Dev K, Lahiri S, Dixit M, Trivedi R, Singh D, Maurya R. Osteogenic activity of natural diterpenoids isolated from Cupressus sempervirens fruits in calvarial derived osteoblast cells via differentiation and mineralization. Phytomedicine. 2014 Dec 15;21(14):1794-800. doi: 10.1016/j.phymed.2014.09.004. Epub 2014 Nov 6. PMID: 25481392.

    7. Verma V, Sharma V, Singh V, Kumar R, Khan MF, Singh AK, Sharma R, Arya KR, Maikhuri JP, Dalela D, Maurya R, Gupta G. Labda-8(17),12,14-trien -19-oic acid contained in fruits of Cupressus sempervirens suppresses benign prostatic hyperplasia in rat and in vitro human models through inhibition of androgen and STAT-3 signaling. Phytother Res. 2014 Aug;28(8):1196-203. doi:10.1002/ptr.5114. Epub 2014 Jan 7. PMID: 24399792.

    Category: Plants of temperate zones

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