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Shimeji mushroom, Hypsizygus tessulatus (mycelium)

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    Hypsizygus tessulatus

    In Japan it is Buna-shimeji, Hypsizygus tessulatus or Hypsizygus marmoreus. 91 studies since 2001. According to these studies it was recognized that it could act positively on a large number of pathologies, of which here are some references.

    Studies :

    • Antioxidant (1, 2, 3, 8, 9)
    • Anti-inflammatory (2, 3)
    • Immunomodulator (4)
    • Leukemia (5)
    • Atherosclerosis (6)
    • Cancer (7, 10)
    • Osteoporosis (11)

    1. Xu Q, Wang H, Li T, Chen L, Zheng B, Liu RH. Comparison of phenolics, antioxidant, and antiproliferative activities of two Hypsizygus marmoreus varieties. J Food Sci. 2020 Jul;85(7):2227-2235. doi:10.1111/1750-3841.15173. Epub 2020 Jun 2. PMID: 32485027.

    2. Liu M, Yao W, Zhu Y, Liu H, Zhang J, Jia L. Characterization, antioxidant and antiinflammation of mycelia selenium polysaccharides from Hypsizygus marmoreus SK-03. Carbohydr Polym. 2018 Dec 1;201:566-574. doi: 10.1016/j.carbpol.2018.08.099. Epub 2018 Aug 26. PMID: 30241854.

    3. Min Liu, Shangshang Li, Xiuxiu Wang, Yongfa Zhu, Jianjun Zhang, Hui Liu, Le Jia,
    Characterization, anti-oxidation and anti-inflammation of polysaccharides by Hypsizygus marmoreus against LPS-induced toxicity on lung ,
    International Journal of Biological Macromolecules,
    Volume 111, 2018, Pages 121-128, ISSN 0141-8130,
    https://doi.org/10.1016/j.ijbiomac.2018.01.010.

    4. Bao HH, Tarbasa M, Chae HM, You SG. Molecular properties of water-unextractable proteoglycans from Hypsizygus marmoreus and their in vitro immunomodulatory activities . Molecules. 2011 Dec 27;17(1):207-26. doi:10.3390/molecules17010207. PMID: 22202808; PMCID: PMC6269059.

    5. Tsai PF, Ma CY, Wu JS. A novel glycoprotein from mushroom Hypsizygus marmoreus (Peck) Bigelow with growth inhibitory effect against human leukemic U937 cells . Food Chem. 2013 Nov 15;141(2):1252-8. doi: 10.1016/j.foodchem.2013.04.024. Epub 2013 Apr 18. PMID: 23790910.

    6. Mori K, Kobayashi C, Tomita T, Inatomi S, Ikeda M. A ntiatherosclerotic effect of the edible mushrooms Pleurotus eryngii (Eringi), Grifola frondosa (Maitake), and Hypsizygus marmoreus (Bunashimeji) in apolipoprotein E-deficient mice. Nutr Res. 2008 May;28(5):335-42. doi: 10.1016/j.nutres.2008.03.010. PMID: 19083429.

    7. Wong JH, Sze SCW, Ng TB, Cheung RCF, Tam C, Zhang KY, Dan X, Chan YS, Cho WC, Ng CCW, Waye MMY, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye Curr Med Chem. 2018;25(40):5613-5630. doi:10.2174/0929867324666170720165005. PMID: 28730971.

    8. Yan J, Zhu L, Qu Y, Qu X, Mu M, Zhang M, Muneer G, Zhou Y, Sun L. Analyzes of active antioxidant polysaccharides from four edible mushrooms. Int J Biol Macromol. 2019 Feb 15;123:945-956. doi: 10.1016/j.ijbiomac.2018.11.079. Epub 2018 Nov 15. PMID: 30447375.

    9. Qu Y, Yan J, Zhang X, Song C, Zhang M, Mayo KH, Sun L, Cheng H, Zhou Y. Structure and antioxidant activity of six mushroom-derived heterogalactans . Int J Biol Macromol. 2022 Jun 1;209(Pt A):1439-1449. doi: 10.1016/j.ijbiomac.2022.04.135. Epub 2022 Apr 22. PMID: 35461867.

    10. Saad HM, Sim KS, Tan YS. Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms . Int J Med Mushrooms. 2018;20(2):141-153. doi: 10.1615/IntJMedMushrooms.2018025463. PMID: 29773006.

    11. Tanaka T, Onuma H, Shigihara T, Kimura E, Fukuta Y, Shirasaka N, Moriyama T, Homma Y. Anti-osteoporotic effects of syringic acid and vanilic acid in the extracts of waste beds after mushroom cultivation . J Biosci Bioeng. 2019 Nov;128(5):622-629. doi: 10.1016/j.jbiosc.2019.04.021. Epub 2019 Jun 8. PMID: 31186185.

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